McKenna K, Smith D, Tormey W, Thompson C J
Dept of Diabetes, Beaumont Hospital, Dublin, Ireland.
Diabet Med. 2000 Jul;17(7):512-7. doi: 10.1046/j.1464-5491.2000.00318.x.
To examine the effect of acute hyperglycaemia on atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) concentrations in Type 1 diabetes.
The study was two limb, randomized, and single-blind. Eight Type 1 diabetes subjects were clamped at euglycaemia by intravenous infusion of insulin. When euglycaemia was established, the insulin infusion rate was left unaltered for the remainder of the protocol, and an intravenous infusion of either 500 ml 0.9% saline or 500 ml 10% dextrose was administered over 1 h. Blood was collected for estimation of plasma glucose, ANP and BNP concentrations at 30 min intervals for 2 h from the start of the infusion period. One week later, each subject received the alternate infusion. Results are expressed as mean +/- standard deviation, and were analysed by ANOVA.
Baseline plasma glucose (P = 0.8), ANP (P = 0.8) and BNP (P = 0.8) concentrations were similar on the study days. Plasma glucose rose with dextrose (6.1 + 0.5-15.1 + 2.8 mmol/l, P = 0.9). Plasma ANP concentrations were unaltered by saline infusion (76.5 +/- 14.7-77.7 +/- 15.2 pg/ml, P = 0.9), but increased with dextrose infusion (79 +/- 14-134 +/- 17.1 pg/ml, P < 0.0001), and were higher with dextrose than saline infusion (P < 0.0001). Plasma concentrations of BNP were not significantly altered by infusion of either dextrose (5.1 +/- 3.9-9.3 +/- 5.4 pg/ml, P = 0.63) or saline (4.3 +/- 3.5-6 +/- 5.2 pg/ml, P = 0.84).
Plasma concentrations of ANP, but not BNP, rise in response to acute hyperglycaemia in Type 1 diabetes.
研究急性高血糖对1型糖尿病患者心房利钠肽（ANP）和脑利钠肽（BNP）浓度的影响。
本研究为双组、随机、单盲试验。8名1型糖尿病受试者通过静脉输注胰岛素维持血糖正常。血糖正常后，在研究剩余阶段胰岛素输注速率保持不变，1小时内静脉输注500毫升0.9%生理盐水或500毫升10%葡萄糖。从输注开始后的2小时内，每隔30分钟采集血液，用于测定血浆葡萄糖、ANP和BNP浓度。一周后，每位受试者接受另一种输注。结果以平均值±标准差表示，并采用方差分析进行分析。
研究期间的基线血浆葡萄糖（P = 0.8）、ANP（P = 0.8）和BNP（P = 0.8）浓度相似。葡萄糖输注后血浆葡萄糖升高（6.1 + 0.5 - 15.1 + 2.8毫摩尔/升，P = 0.9）。生理盐水输注后血浆ANP浓度未改变（从76.5 ± 14.7皮克/毫升至77.7 ± 15.2皮克/毫升，P = 0.9），但葡萄糖输注后升高（从79 ± 14皮克/毫升至134 ± 17.1皮克/毫升，P < 0.0001），且葡萄糖输注后的浓度高于生理盐水输注（P < 0.0001）。葡萄糖输注（从5.1 ± 3.9皮克/毫升至9.3 ± 5.4皮克/毫升，P = 0.63）或生理盐水输注（从4.3 ± 3.5皮克/毫升至6 ± 5.2皮克/毫升，P = 0.84）后，血浆BNP浓度均无显著改变。
1型糖尿病患者急性高血糖时，血浆ANP浓度升高，而BNP浓度无变化。
