Shaco-Levy R, Sion-Vardy N, Piura B
Department of Pathology, Soroka Medical Center and Faculty of Health Schiences, Beer-Sheva, Israel.
Eur J Gynaecol Oncol. 2005;26(5):509-10.
Primary extragenital malignant mixed Müllerian tumors (MMMTs) are very rare neoplasms, with only 28 documented cases in the literature. Two cases coexisted with a colonic adenocarcinoma.
We report on a primary peritoneal MMMT diagnosed shortly after resection of a colonic adenocarcinoma in an 85-year-old woman who presented with a large omental mass. Microscopic examination revealed a biphasic tumor with malignant carcinomatous and sarcomatous components, confirmed immunohistochemically, consistent with MMMT. Despite optimal debulking and uneventful postoperative recovery, the patient died of her disease shortly after surgery due to recurrent disseminated disease.
This is the third case in the literature of primary extragenital MMMT occurring in association with colonic adenocarcinoma. This coexistence may be incidental, but it may also imply a possible linkage between these two tumors.
原发性生殖器外恶性混合性苗勒管肿瘤（MMMTs）是非常罕见的肿瘤，文献中仅有28例记录。有2例与结肠腺癌共存。
我们报告1例85岁女性，在切除结肠腺癌后不久诊断出原发性腹膜MMMT，该患者表现为大网膜肿块。显微镜检查显示为具有恶性癌性和肉瘤性成分的双相肿瘤，经免疫组化证实，符合MMMT。尽管进行了最佳的肿瘤减灭术且术后恢复顺利，但患者术后不久因疾病复发播散而死于该病。
这是文献中第三例原发性生殖器外MMMT与结肠腺癌相关的病例。这种共存可能是偶然的，但也可能意味着这两种肿瘤之间存在潜在联系。
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