激烈交锋：微调p53-PUMA死亡关联
Slugging it out: fine tuning the p53-PUMA death connection.
作者信息
Zilfou Jack T, Spector Mona S, Lowe Scott W
机构信息
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.
出版信息
Cell. 2005 Nov 18;123(4):545-8. doi: 10.1016/j.cell.2005.11.003.
Abstract
In response to DNA damage, the tumor suppressor p53 elicits a complex cellular response. In this issue of Cell, Wu et al. (2005) show that the transcription factor SLUG is induced by p53 and protects hematopoietic progenitor cells from apoptosis triggered by DNA damage. SLUG exerts this protective role by repressing Puma, a proapoptotic target of p53. PUMA is also a key coordinator of apoptosis mediated by both nuclear and cytoplasmic functions of p53 (Chi-puk et al., 2005).
摘要
作为对DNA损伤的反应，肿瘤抑制因子p53引发复杂的细胞反应。在本期《细胞》杂志中，吴等人（2005年）表明，转录因子SLUG由p53诱导产生，并保护造血祖细胞免受DNA损伤引发的凋亡。SLUG通过抑制Puma发挥这种保护作用，Puma是p53的一个促凋亡靶点。PUMA也是由p53的核功能和细胞质功能介导的凋亡的关键协调因子（Chi-puk等人，2005年）。
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本文引用的文献
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