Csernansky John G, Wang Lei, Miller J Philip, Galvin James E, Morris John C
Alzheimer's Disease Research Center, and Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA.
Arch Neurol. 2005 Nov;62(11):1718-22. doi: 10.1001/archneur.62.11.1718.
Patients with dementia of the Alzheimer type (DAT) respond variably to treatment with acetylcholinesterase inhibitors.
To determine whether measures of hippocampal volume and shape predict the response to donepezil in patients with DAT.
T1-weighted, magnetic resonance images were obtained from patients with DAT, who subsequently underwent treatment with donepezil. Brain-mapping algorithms were used to quantify hippocampal volume and shape, and growth curves were used to estimate clinical outcome.
A referral outpatient center specializing in treatment of dementia.
Thirty-seven patients with very mild or mild DAT received donepezil therapy for up to 4 weeks before magnetic resonance imaging and for 24 to 96 weeks after magnetic resonance imaging.
Donepezil, 10 mg/d.
Rate of change in the cognitive portion of the Alzheimer's Disease Assessment Scale total scores.
Smaller hippocampal volume and inward variation of the lateral and inferomedial portions of the hippocampal surface were correlated with a poorer response to donepezil therapy.
Measures of hippocampal volume and surface variation can be used to predict the response of patients with DAT to the acetylcholinesterase inhibitor donepezil.
阿尔茨海默型痴呆（DAT）患者对乙酰胆碱酯酶抑制剂治疗的反应各不相同。
确定海马体积和形状的测量指标是否能预测DAT患者对多奈哌齐的反应。
从DAT患者中获取T1加权磁共振图像，这些患者随后接受多奈哌齐治疗。使用脑图谱算法量化海马体积和形状，并使用生长曲线估计临床结果。
一家专门治疗痴呆症的转诊门诊中心。
37例极轻度或轻度DAT患者在磁共振成像前接受多奈哌齐治疗长达4周，在磁共振成像后接受24至96周治疗。
多奈哌齐，10毫克/天。
阿尔茨海默病评估量表总分认知部分的变化率。
较小的海马体积以及海马表面外侧和下内侧部分的向内变化与对多奈哌齐治疗的较差反应相关。
海马体积和表面变化的测量指标可用于预测DAT患者对乙酰胆碱酯酶抑制剂多奈哌齐的反应。
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