Rajguru Suhrud M, Ifediba Marytheresa A, Rabbitt Richard D
Department of Bioengineering, University of Utah, Salt Lake City, UT - 84112, USA.
J Vestib Res. 2005;15(4):203-14.
Horizontal canal (HC) benign paroxysmal positional vertigo (HC-BPPV) is a vestibular disorder characterized by bouts of horizontal ocular nystagmus induced during reorientation of the head relative to gravity. The present report addresses the application of a morphologically descriptive 3-canal biomechanical model of the human membranous labyrinth to study gravity-dependent semicircular canal responses during this condition. The model estimates dynamic cupular and endolymph displacements elicited during HC-BPPV provocative diagnostic maneuvers and canalith repositioning procedures (CRPs). The activation latencies in response to an HC-BPPV provocative diagnostic test were predicted to vary depending upon the initial location of the canalith debris (e.g. within the HC lumen vs. in the ampulla). Results may explain why the onset latency of ocular nystagmus evoked by the Dix-Hallpike provocative maneuver for posterior canal BPPV are typically longer than the latencies evoked by analogous tests for HC-BPPV. The model was further applied to assess the efficacy of a 360 degrees -rotation CRP for the treatment of canalithiasis HC-BPPV.
水平半规管（HC）良性阵发性位置性眩晕（HC-BPPV）是一种前庭疾病，其特征是头部相对于重力重新定向时诱发水平性眼球震颤发作。本报告阐述了人类膜迷路的形态学描述性三半规管生物力学模型在研究这种情况下重力依赖性半规管反应中的应用。该模型估计了HC-BPPV激发性诊断操作和耳石复位程序（CRP）期间诱发的动态壶腹嵴帽和内淋巴位移。预计对HC-BPPV激发性诊断测试的反应激活潜伏期会因耳石碎片的初始位置而异（例如，在水平半规管管腔内与壶腹中）。结果可能解释了为什么用于后半规管BPPV的Dix-Hallpike激发性操作诱发的眼球震颤发作潜伏期通常比HC-BPPV类似测试诱发的潜伏期更长。该模型还被用于评估360度旋转CRP治疗耳石症性HC-BPPV的疗效。
