镓（III）和铟（III）的含碳水化合物的3-羟基-4-吡啶酮配合物

Carbohydrate-bearing 3-hydroxy-4-pyridinonato complexes of gallium(III) and indium(III).

作者信息

Green David E, Ferreira Cara L, Stick Robert V, Patrick Brian O, Adam Michael J, Orvig Chris

机构信息

Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, Vancouver, BC, V6T 1Z1, Canada.

出版信息

Bioconjug Chem. 2005 Nov-Dec;16(6):1597-609. doi: 10.1021/bc0501808.

DOI:10.1021/bc0501808

PMID:16287260

Abstract

Gallium and indium complexes with pendant carbohydrates have been prepared and examined for their potential as radiopharmaceuticals. Carbohydrate-bearing 3-hydroxy-4-pyridinone ligand precursors and their tris(ligand)gallium(III) and -indium(III) complexes were synthesized and characterized by mass spectrometry, elemental analysis, and (1)H and (13)C NMR spectroscopy, and in the case of one intermediate, by X-ray crystallography. With three equivalents of ligand, neutral complexes formed with the bidentate hydroxypyridinone moiety complexing the gallium(III) and indium(III) metal centers.

摘要

已制备出带有侧链碳水化合物的镓和铟配合物，并对其作为放射性药物的潜力进行了研究。合成了含碳水化合物的3-羟基-4-吡啶酮配体前体及其三（配体）镓（III）和铟（III）配合物，并通过质谱、元素分析、（1）H和（13）C核磁共振光谱进行了表征，对于一种中间体，还通过X射线晶体学进行了表征。使用三当量的配体时，会形成中性配合物，其中双齿羟基吡啶酮部分与镓（III）和铟（III）金属中心络合。