• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Efficient synthesis of 5-amido-3-hydroxy-4-pyrones as inhibitors of matrix metalloproteinases.5-氨基-3-羟基-4-吡喃酮作为基质金属蛋白酶抑制剂的高效合成。
Org Lett. 2007 Jun 21;9(13):2517-20. doi: 10.1021/ol0707665. Epub 2007 May 24.
2
Synthesis of hydroxypyrone- and hydroxythiopyrone-based matrix metalloproteinase inhibitors: developing a structure-activity relationship.基于羟基吡喃酮和羟基噻喃酮的基质金属蛋白酶抑制剂的合成：建立构效关系
Bioorg Med Chem Lett. 2009 Apr 1;19(7):1970-6. doi: 10.1016/j.bmcl.2009.02.044. Epub 2009 Feb 14.
3
Emergence of 2-Pyrone and Its Derivatives, from Synthesis to Biological Perspective: An Overview and Current Status.2-吡喃酮及其衍生物的兴起：从合成到生物视角的概述与现状。
Top Curr Chem (Cham). 2021 Sep 23;379(6):38. doi: 10.1007/s41061-021-00350-w.
4
Pyrone-based inhibitors of metalloproteinase types 2 and 3 may work as conformation-selective inhibitors.基于吡咯酮的金属蛋白酶 2 和 3 的抑制剂可能作为构象选择性抑制剂发挥作用。
Chem Biol Drug Des. 2011 Aug;78(2):191-8. doi: 10.1111/j.1747-0285.2011.01148.x. Epub 2011 Jun 20.
5
Structure-based design of HIV protease inhibitors: 5,6-dihydro-4-hydroxy-2-pyrones as effective, nonpeptidic inhibitors.基于结构的HIV蛋白酶抑制剂设计：5,6-二氢-4-羟基-2-吡喃酮作为有效的非肽类抑制剂
J Med Chem. 1996 Nov 8;39(23):4630-42. doi: 10.1021/jm960228q.
6
Potent, selective pyrone-based inhibitors of stromelysin-1.强效、选择性的基于吡喃酮的基质金属蛋白酶-1抑制剂。
J Am Chem Soc. 2005 Oct 19;127(41):14148-9. doi: 10.1021/ja054558o.
7
Efficacy of a series of alpha-pyrone derivatives against Leishmania (L.) infantum and Trypanosoma cruzi.一系列α-吡喃酮衍生物对婴儿利什曼原虫和克氏锥虫的疗效。
Eur J Med Chem. 2017 Oct 20;139:947-960. doi: 10.1016/j.ejmech.2017.08.055. Epub 2017 Sep 1.
8
Synthesis and HIV protease inhibitory activity of new 4-hydroxy-2-pyrone derivatives.新型4-羟基-2-吡喃酮衍生物的合成及其对HIV蛋白酶的抑制活性
Arch Pharm (Weinheim). 2000 Oct;333(10):319-22. doi: 10.1002/1521-4184(200010)333:10<319::aid-ardp319>3.0.co;2-a.
9
Synthesis and biological evaluation of kojic acid derivatives containing 1,2,4-triazole as potent tyrosinase inhibitors.含1,2,4-三唑的曲酸衍生物作为高效酪氨酸酶抑制剂的合成及生物学评价
Chem Biol Drug Des. 2015 Nov;86(5):1087-92. doi: 10.1111/cbdd.12577. Epub 2015 May 14.
10
One-pot regio- and stereoselective synthesis of α'-methoxy-γ-pyrones: biological evaluation as mitochondrial respiratory complex inhibitors.一锅法区域和立体选择性合成 α'-甲氧基-γ-吡喃酮：作为线粒体呼吸复合物抑制剂的生物学评价。
J Org Chem. 2011 Nov 18;76(22):9429-37. doi: 10.1021/jo201683u. Epub 2011 Oct 27.

引用本文的文献

1
Benzimidazolium quaternary ammonium salts: synthesis, single crystal and Hirshfeld surface exploration supported by theoretical analysis.苯并咪唑鎓季铵盐：合成、单晶及理论分析支持下的 Hirshfeld 表面探究
R Soc Open Sci. 2024 Feb 14;11(2):231094. doi: 10.1098/rsos.231094. eCollection 2024 Feb.
2
Hydroxypyrone derivatives in drug discovery: from chelation therapy to rational design of metalloenzyme inhibitors.药物研发中的羟基吡喃酮衍生物：从螯合疗法到金属酶抑制剂的合理设计
RSC Med Chem. 2022 Jul 29;13(10):1127-1149. doi: 10.1039/d2md00175f. eCollection 2022 Oct 19.
3
Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease.金属结合药效团在流感内切酶中的结构-活性关系。
J Med Chem. 2018 Nov 21;61(22):10206-10217. doi: 10.1021/acs.jmedchem.8b01363. Epub 2018 Oct 31.
4
Matrix Metalloproteinase Inhibitors as Investigational and Therapeutic Tools in Unrestrained Tissue Remodeling and Pathological Disorders.基质金属蛋白酶抑制剂作为无节制组织重塑和病理紊乱中的研究及治疗工具
Prog Mol Biol Transl Sci. 2017;148:355-420. doi: 10.1016/bs.pmbts.2017.04.003. Epub 2017 May 10.
5
Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins.基质金属蛋白酶作为与静脉曲张相关静脉扩张的潜在靶点。
Curr Drug Targets. 2013 Mar;14(3):287-324.
6
Effect of Alpinia zerumbet components on antioxidant and skin diseases-related enzymes.高良姜成分对抗氧化和皮肤病相关酶的影响。
BMC Complement Altern Med. 2012 Jul 24;12:106. doi: 10.1186/1472-6882-12-106.
7
Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease.基质金属蛋白酶抑制剂作为血管疾病发病机制及治疗研究的工具
Exp Suppl. 2012;103:209-79. doi: 10.1007/978-3-0348-0364-9_7.
8
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.基于片段的方法鉴定金属蛋白酶抑制剂的螯合剂。
J Med Chem. 2011 Jan 27;54(2):591-602. doi: 10.1021/jm101266s. Epub 2010 Dec 28.
9
Synthesis of hydroxypyrone- and hydroxythiopyrone-based matrix metalloproteinase inhibitors: developing a structure-activity relationship.基于羟基吡喃酮和羟基噻喃酮的基质金属蛋白酶抑制剂的合成：建立构效关系
Bioorg Med Chem Lett. 2009 Apr 1;19(7):1970-6. doi: 10.1016/j.bmcl.2009.02.044. Epub 2009 Feb 14.

本文引用的文献

1
Matrix metalloproteinases and the regulation of tissue remodelling.基质金属蛋白酶与组织重塑的调控
Nat Rev Mol Cell Biol. 2007 Mar;8(3):221-33. doi: 10.1038/nrm2125.
2
From miso, saké and shoyu to cosmetics: a century of science for kojic acid.从味噌、清酒和酱油到化妆品：曲酸的百年科学历程
Nat Prod Rep. 2006 Dec;23(6):1046-62. doi: 10.1039/b603758p. Epub 2006 Oct 18.
3
Kojic acid and its manganese and zinc complexes as potential radioprotective agents.曲酸及其锰和锌配合物作为潜在的辐射防护剂。
Bioorg Med Chem Lett. 2007 Jan 1;17(1):45-8. doi: 10.1016/j.bmcl.2006.09.097. Epub 2006 Oct 4.
4
Spectroscopic and potentiometric characterization of oxovanadium(IV) complexes formed by 3-hydroxy-4-pyridinones. Rationalization of the influence of basicity and electronic structure of the ligand on the properties of V(IV)O species in aqueous solution.由3-羟基-4-吡啶酮形成的氧钒（IV）配合物的光谱和电位表征。配体的碱性和电子结构对水溶液中V（IV）O物种性质影响的合理化解释。
Inorg Chem. 2006 Oct 2;45(20):8086-97. doi: 10.1021/ic0605571.
5
Evaluation and binding-mode prediction of thiopyrone-based inhibitors of anthrax lethal factor.基于硫代吡喃酮的炭疽致死因子抑制剂的评估及结合模式预测
ChemMedChem. 2006 Jul;1(7):694-7. doi: 10.1002/cmdc.200600102.
6
Metal complexes of maltol and close analogues in medicinal inorganic chemistry.药用无机化学中麦芽酚及其类似物的金属配合物。
Chem Soc Rev. 2006 Jun;35(6):545-56. doi: 10.1039/b416256k. Epub 2006 Apr 12.
7
Tris(pyrone) chelates of Gd(III) as high solubility MRI-CA.钆（III）的三（吡喃酮）螯合物作为高溶解度的磁共振成像造影剂。
J Am Chem Soc. 2006 Feb 22;128(7):2222-3. doi: 10.1021/ja057954f.
8
Heterocyclic zinc-binding groups for use in next-generation matrix metalloproteinase inhibitors: potency, toxicity, and reactivity.用于下一代基质金属蛋白酶抑制剂的杂环锌结合基团：效力、毒性和反应性。
J Biol Inorg Chem. 2006 Mar;11(2):131-8. doi: 10.1007/s00775-005-0053-x. Epub 2005 Dec 3.
9
Carbohydrate-bearing 3-hydroxy-4-pyridinonato complexes of gallium(III) and indium(III).镓（III）和铟（III）的含碳水化合物的3-羟基-4-吡啶酮配合物
Bioconjug Chem. 2005 Nov-Dec;16(6):1597-609. doi: 10.1021/bc0501808.
10
Potent, selective pyrone-based inhibitors of stromelysin-1.强效、选择性的基于吡喃酮的基质金属蛋白酶-1抑制剂。
J Am Chem Soc. 2005 Oct 19;127(41):14148-9. doi: 10.1021/ja054558o.

5-氨基-3-羟基-4-吡喃酮作为基质金属蛋白酶抑制剂的高效合成。

Efficient synthesis of 5-amido-3-hydroxy-4-pyrones as inhibitors of matrix metalloproteinases.

作者信息

Yan Yi-Long, Cohen Seth M

机构信息

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0358, USA.

出版信息

Org Lett. 2007 Jun 21;9(13):2517-20. doi: 10.1021/ol0707665. Epub 2007 May 24.

DOI:10.1021/ol0707665
PMID:17521196
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2531216/
Abstract

3-hydroxy-4-pyrones are a class of important metal chelators with versatile medicinal applications. An efficient pathway for the preparation of new 5-amido-3-hydroxy-4-pyrone derivatives has been developed. The synthesized 5-amido-3-hydroxy-4-pyrones have been evaluated as inhibitors of matrix metalloproteinases.

摘要

3-羟基-4-吡喃酮是一类重要的金属螯合剂，具有多种医学应用。已开发出一种制备新型5-酰胺基-3-羟基-4-吡喃酮衍生物的有效途径。所合成的5-酰胺基-3-羟基-4-吡喃酮已被评估为基质金属蛋白酶的抑制剂。