Sachs George, Weeks David L, Wen Yi, Marcus Elizabeth A, Scott David R, Melchers Klaus
Laboratory of Membrane Biology, David Geffen School of Medicine at the University of California-Los Angeles, USA.
Physiology (Bethesda). 2005 Dec;20:429-38. doi: 10.1152/physiol.00032.2005.
Helicobacter pylori is a Gram-negative neutralophile associated with peptic ulcers and gastric cancer. It has a unique ability to colonize the human stomach by acid acclimation. It uses the pH-gated urea channel, UreI, to enhance urea access to intrabacterial urease and a membrane-anchored periplasmic carbonic anhydrase to regulate periplasmic pH to approximately 6.1 in acidic media, whereas other neutralophiles cannot regulate periplasmic pH and thus only transit the stomach.
幽门螺杆菌是一种与消化性溃疡和胃癌相关的革兰氏阴性嗜中性菌。它具有通过适应酸性环境在人类胃部定殖的独特能力。它利用pH门控尿素通道UreI来增加尿素进入细菌内脲酶的机会，并利用一种膜锚定的周质碳酸酐酶在酸性介质中将周质pH调节至约6.1，而其他嗜中性菌无法调节周质pH，因此只能通过胃部。
