Ballauff A, Eggert A
Universitätsklinikum Essen, Kinderklinik, Pädiatrische Gastroenterologie und Hepatologie.
Klin Padiatr. 2005 Nov;217 Suppl 1:S101-9. doi: 10.1055/s-2005-872504.
Common complications involved in treating pediatric patients with cancer are bacterial, viral and fungal infections of the gastrointestinal tract including esophagitis, gastritis, duodenitis, colitis and hepatobiliar infections. In many cases there are multiple factors that predispose these patients to gastrointestinal infections, such as granulocytopenia, T-cell dysfunction, and mucosal damage. In addition, newer therapies have changed the spectrum of infection that is seen in these patients. The profound T-cell suppression associated with therapies such as stem cell transplantation has led to the emergence of previously rare infections including cytomegalovirus and adenovirus. This article provides the recommendations of the Infectious Diseases Working Party of the German Society for Pediatric Infectious Diseases (DGPI) and the German Society for Pediatric Hematology/Oncology (GPOH) for diagnosis, prevention, and management of local as well as invasive infections of the gastrointestinal tract.
治疗患癌儿童患者时常见的并发症是胃肠道的细菌、病毒和真菌感染，包括食管炎、胃炎、十二指肠 炎、结肠炎和肝胆感染。在许多情况下，有多种因素使这些患者易患胃肠道感染，如粒细胞减少、T 细胞功能障碍和黏膜损伤。此外，新的治疗方法改变了这些患者中所见感染的类型。与干细胞移植等治疗相关的深度 T 细胞抑制导致了包括巨细胞病毒和腺病毒在内的以前罕见的感染的出现。本文提供了德国儿科传染病学会（DGPI）和德国儿科血液学/肿瘤学会（GPOH）传染病工作组关于胃肠道局部和侵袭性感染的诊断、预防和管理的建议。
