Muñoz Patricia, Fogeda Marta, Bouza Emilio, Verde Eduardo, Palomo Jesus, Bañares Rafael
Department of Clinical Microbiology-Infectious Diseases, Hospital General Universitario Gregorio Maranon, University of Madrid, Madrid, Spain.
Clin Infect Dis. 2005 Dec 15;41(12):1720-5. doi: 10.1086/498118. Epub 2005 Nov 10.
BK virus (BKV) has been implicated as a cause of nephritis and graft loss in 2%-9% of kidney transplant recipients, but the prevalence among recipients of other solid organ transplants (SOTs) has not been well established. Our objective was to determine the prevalence of BKV infection for all types of SOT recipients at our medical center.
A total of 156 consecutive SOT recipients were studied, of whom 49 received kidney transplants, 43 received heart transplants, and 64 received liver transplants. Samples were obtained a median of 559 days (range, 1-9481 days) after transplantation. Nested polymerase chain reaction was performed for detection of BKV DNA in urine and plasma specimens.
BKV was found in 19% of urine specimens and 6% of plasma specimens. The prevalence of viruria after kidney, heart, and liver transplantation was 26.5%, 25.5%, and 7.8%, respectively. BKV viremia was detected in 12.2% of kidney transplant recipients and 7% of heart transplant recipients. Mean creatinine levels were higher in patients with BKV viruria or viremia (1.9 and 3.5 mg/dL, respectively) than in patients with no BKV replication (1.3 mg/dL). Independent factors related to impaired renal function were renal transplantation (odds ratio [OR], 14.4); BKV replication, including viruria or viremia (OR, 3.3); and mycophenolate use (OR, 2.6).
BKV is common in all types of SOT recipients, particularly those who have received heart or kidney transplants.
BK病毒（BKV）被认为是2%-9%的肾移植受者发生肾炎和移植肾失功的病因，但在其他实体器官移植（SOT）受者中的流行情况尚未完全明确。我们的目的是确定在我们医疗中心所有类型的SOT受者中BKV感染的流行情况。
共研究了156例连续的SOT受者，其中49例接受肾移植，43例接受心脏移植，64例接受肝脏移植。在移植后中位数559天（范围1-9481天）采集样本。采用巢式聚合酶链反应检测尿液和血浆标本中的BKV DNA。
19%的尿液标本和6%的血浆标本中检测到BKV。肾移植、心脏移植和肝移植后病毒尿的发生率分别为26.5%、25.5%和7.8%。12.2%的肾移植受者和7%的心脏移植受者检测到BKV病毒血症。BKV病毒尿或病毒血症患者的平均肌酐水平（分别为1.9和3.5mg/dL）高于无BKV复制的患者（1.3mg/dL）。与肾功能受损相关的独立因素为肾移植（比值比[OR]，14.4）；BKV复制，包括病毒尿或病毒血症（OR，3.3）；以及霉酚酸酯的使用（OR，2.6）。
BKV在所有类型的SOT受者中都很常见，尤其是接受心脏或肾移植的受者。
