Liu Gang, Chen Xinbin
Department of Cell Biology, The University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294, USA.
J Cell Biochem. 2006 Feb 15;97(3):448-58. doi: 10.1002/jcb.20700.
In response to various stresses, p53 is rapidly activated and transcriptionally regulates a number of target genes by which p53 modulates a variety of cellular activities. The transcriptional activity of p53 is delicately regulated by a plethora of cellular factors, independently or synergistically, in multiple ways in order to achieve a specific response. This article reviewed the role of the basal transcriptional machinery, co-activators, and co-repressors involved in p53-dependent transcription, and the underlying mechanism by which the p53 transcriptional activity is regulated. We also discussed some potentially interesting questions and future directions in the field.
响应各种应激时，p53会迅速被激活，并通过转录调控多个靶基因，借此p53调节多种细胞活动。p53的转录活性受到众多细胞因子的精细调控，这些因子以多种方式独立或协同作用，以实现特定的反应。本文综述了参与p53依赖性转录的基础转录机制、共激活因子和共抑制因子的作用，以及p53转录活性受调控的潜在机制。我们还讨论了该领域一些潜在有趣的问题和未来方向。
