一种将不对称镍/铬介导的偶联反应从化学计量转化为催化的新方法。

A new method for translating the asymmetric Ni/Cr-mediated coupling reactions from stoichiometric to catalytic.

作者信息

Namba Kosuke, Cui Sheng, Wang Jiashi, Kishi Yoshito

机构信息

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

出版信息

Org Lett. 2005 Nov 24;7(24):5417-9. doi: 10.1021/ol052084s.

DOI:10.1021/ol052084s

PMID:16288520

Abstract

[reaction: see text] A new method has been developed for effectively translating the degree of asymmetric induction and the chemical yield achieved in the stoichiometric asymmetric Ni/Cr-mediated coupling to a catalytic asymmetric process via a chiral sulfonamide ligand. It has also been shown that the Ni catalyst plays a central role. Among a number of the Ni catalysts, the 2,9-dimethylphenanthroline/NiCl(2) complex (7) has been found to be the most effective.

摘要

[反应：见正文] 已经开发出一种新方法，可通过手性磺酰胺配体有效地将化学计量不对称镍/铬介导偶联中实现的不对称诱导程度和化学产率转化为催化不对称过程。还表明镍催化剂起着核心作用。在众多镍催化剂中，已发现2,9-二甲基菲咯啉/NiCl₂络合物（7）最为有效。