不对称镍（II）/铬（II）介导的偶联反应：催化过程。

Asymmetric Ni(II)/Cr(II)-mediated coupling reaction: catalytic process.

作者信息

Choi Hyeong-Wook, Nakajima Katsumasa, Demeke Damtew, Kang Fu-An, Jun Hyuk-Sang, Wan Zhao-Kui, Kishi Yoshito

机构信息

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

出版信息

Org Lett. 2002 Dec 12;4(25):4435-8. doi: 10.1021/ol026981x.

DOI:10.1021/ol026981x

PMID:12465906

Abstract

[reaction: see text] The stable, crystalline Cr(III)/sulfonamide complex 1a is shown to be an effective catalyst for the Ni/Cr-mediated coupling reaction. A possible mechanism is suggested for the process. 1a is also effective for other Cr-mediated coupling reactions. With this catalyst, a concise and efficient synthesis of the C14-C26 segment of halichondrins has been developed.

摘要

[反应：见正文] 稳定的结晶态Cr(III)/磺酰胺配合物1a被证明是Ni/Cr介导的偶联反应的有效催化剂。文中提出了该过程的一种可能机理。1a对其他Cr介导的偶联反应也有效。使用这种催化剂，已开发出一种简洁高效的海兔毒素C14 - C26片段的合成方法。