Woodward Angela R, Burks Heather E, Chan Louis M, Morken James P
Department of Chemistry, Venable and Kenan Laboratories, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA.
Org Lett. 2005 Nov 24;7(24):5505-7. doi: 10.1021/ol052312i.
[reaction: see text] Palladium-catalyzed enantioselective diboration of prochiral allenes generates a reactive chiral allylboron intermediate which is a versatile reagent for the allylation of carbonyls. Experiments that improve the enantioselectivity of this process, examine the substrate scope, and are directed toward functionalization of the allylation intermediate are described.
[反应：见正文] 钯催化前手性联烯的对映选择性双硼化反应生成一种活性手性烯丙基硼中间体，该中间体是用于羰基烯丙基化反应的通用试剂。本文描述了提高该反应对映选择性、考察底物范围以及针对烯丙基化中间体官能团化的实验。
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