Tefferi Ayalew, Dingli David, Li Chin-Yang, Mesa Ruben A
Division of Hematology, 200 First Street SW, Mayo Clinic, Rochester, MN 55905, USA.
Leuk Res. 2006 Jun;30(6):677-80. doi: 10.1016/j.leukres.2005.10.006. Epub 2005 Nov 8.
Microcytosis is a characteristic laboratory feature for both iron deficiency anemia and thalassemia. It is also infrequently seen in "anemia of chronic disease" that accompanies a spectrum of chronic conditions including rheumatoid arthritis, polymyalgia rheumatica, diabetes mellitus, connective tissue disease, and protracted infection. In addition, there is a well established but pathogenetically obscure association of microcytosis with Hodgkin's lymphoma, Castleman's disease, and renal cell carcinoma. In the current study, we show that microcytosis is a frequent laboratory feature in agnogenic myeloid metaplasia and investigate its clinical relevance in the particular setting.
小红细胞症是缺铁性贫血和地中海贫血的一个典型实验室特征。它在伴有一系列慢性病（包括类风湿性关节炎、风湿性多肌痛、糖尿病、结缔组织病和长期感染）的“慢性病贫血”中也不常见。此外，小红细胞症与霍奇金淋巴瘤、卡斯尔曼病和肾细胞癌之间存在一种已确立但发病机制不明的关联。在本研究中，我们表明小红细胞症是原发性骨髓化生中的常见实验室特征，并在特定情况下研究其临床相关性。
