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Stimulatory effect of interleukin-1 beta on the interferon-gamma-dependent HLA-DR production.

作者信息

Tomoda T, Kurashige T, Taniguchi T

机构信息

Department of Pediatrics, Kochi Medical School, Japan.

出版信息

Immunology. 1992 May;76(1):15-9.

PMID:1628893
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1421747/
Abstract

Expression of major histocompatibility complex (MHC) class II genes is induced by interferon-gamma (IFN-gamma) in antigen-presenting cells. When human leukaemia THP-1 and PL-21 cells were pretreated with phorbol ester, IFN-gamma-dependent induction of MHC class II gene was markedly enhanced. To elucidate the mechanism of the phenomenon, we examined the effect of cytokines which were secreted from THP-1 cells by the treatment of phorbol ester. Among those cytokines, interleukin-1 beta (IL-1 beta) had a positive effect on IFN-gamma-dependent induction of MHC class II genes. In order to rule out the possibility that different clones of THP-1 cells respond independently to IFN-gamma or phorbol ester, we showed that all independent single clones expressed MHC class II and produced IL-1 beta by IFN-gamma or phorbol ester, respectively.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e595/1421747/761611381bb0/immunology00104-0020-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e595/1421747/5ba3bc379c74/immunology00104-0018-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e595/1421747/c4f91034b355/immunology00104-0019-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e595/1421747/761611381bb0/immunology00104-0020-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e595/1421747/5ba3bc379c74/immunology00104-0018-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e595/1421747/c4f91034b355/immunology00104-0019-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e595/1421747/761611381bb0/immunology00104-0020-a.jpg

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本文引用的文献

1
Leukaemia virus infection promotes fibroblast transformation by normal BALB/c mouse DNA.
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2
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Cloned human interferon-gamma, but not interferon-beta or -alpha, induces expression of HLA-DR determinants by fetal monocytes and myeloid leukemic cell lines.克隆的人γ干扰素可诱导胎儿单核细胞和髓系白血病细胞系表达HLA - DR决定簇，而β干扰素或α干扰素则无此作用。
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7
Interleukin 2-mediated immune interferon (IFN-gamma) production by human T cells and T cell subsets.白细胞介素2介导人T细胞及T细胞亚群产生免疫干扰素（IFN-γ）。
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Interleukin-1.白细胞介素-1
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Blood. 1984 Feb;63(2):254-9.
10
Interferon-gamma reduces macrophage-suppressive activity by inhibiting prostaglandin E2 release and inducing interleukin 1 production.干扰素-γ通过抑制前列腺素E2释放和诱导白细胞介素1产生来降低巨噬细胞抑制活性。
J Immunol. 1984 Aug;133(2):764-8.