Byers R M, Berkeley R G, Luna M, Jesse R H
Am J Ophthalmol. 1975 Jan;79(1):53-5. doi: 10.1016/0002-9394(75)90455-9.
The medical records of 13 patients with primary malignant lesions of the lacrimal gland revealed adenoid cystic carcinoma as the most common malignant tumor. The histologic cell type, neural invasion, and bony destruction were correlated with localized control and ultimate survival. Surgical removal of the lacrimal gland was adequate treatment for low-grade mucoepidermoid carcinoma confined to the gland itself. Combining a radical surgical removal of the area in planned sequence with high voltage radiation therapy offered the only reasonable hope for localized control in the more aggressive cell types or in tumors with neural invasion or bony involvement. A 40%-localized control and survival rate was achieved in the adenoid cystic carcinoma group of patients. Radiation therapy administered for cancer that obviously recurs after surgical resection was generally unsuccessful.
13例泪腺原发性恶性病变患者的病历显示，腺样囊性癌是最常见的恶性肿瘤。组织学细胞类型、神经侵犯和骨质破坏与局部控制及最终生存率相关。对于局限于泪腺本身的低级别黏液表皮样癌，手术切除泪腺是充分的治疗方法。对于更具侵袭性的细胞类型或伴有神经侵犯或骨质受累的肿瘤，按计划顺序进行根治性手术切除联合高电压放射治疗是实现局部控制的唯一合理希望。腺样囊性癌患者组的局部控制率和生存率为40%。对手术切除后明显复发的癌症进行放射治疗通常不成功。
