Vavouri Tanya, McEwen Gayle K, Woolfe Adam, Gilks Walter R, Elgar Greg
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, CB10 1SA.
Trends Genet. 2006 Jan;22(1):5-10. doi: 10.1016/j.tig.2005.10.005. Epub 2005 Nov 10.
Many conserved non-coding elements (CNEs) in vertebrate genomes have been shown to function as tissue-specific enhancers. However, the target genes of most CNEs are unknown. Here we show that the target genes of duplicated CNEs can be predicted by considering their neighbouring paralogous genes. This enables us to provide the first systematic estimate of the genomic range for distal cis-regulatory interactions in the human genome: half of CNEs are >250 kb away from their associated gene.
脊椎动物基因组中的许多保守非编码元件（CNE）已被证明可作为组织特异性增强子发挥作用。然而，大多数CNE的靶基因尚不清楚。在此我们表明，通过考虑其相邻的旁系同源基因，可以预测重复CNE的靶基因。这使我们能够首次对人类基因组中远端顺式调控相互作用的基因组范围进行系统估计：一半的CNE与其相关基因的距离超过250 kb。
