向大鼠中缝背核微量注射5-羟色胺（7）受体拮抗剂SB-269970对快速眼动睡眠的影响。
Effects of the 5-HT(7) receptor antagonist SB-269970 microinjected into the dorsal raphe nucleus on REM sleep in the rat.
作者信息
Monti Jaime M, Jantos Héctor
机构信息
Department of Pharmacology and Therapeutics, Clinics Hospital, 2833/602 Zudañez Street, Montevideo 11300, Uruguay.
出版信息
Behav Brain Res. 2006 Feb 28;167(2):245-50. doi: 10.1016/j.bbr.2005.09.025. Epub 2005 Nov 11.
The effects of SB-269970, a selective 5-HT(7) receptor antagonist, on spontaneous sleep were studied in adult rats implanted for chronic sleep recordings. SB-269970 was infused directly into the dorsal raphe nucleus (DRN) during the light phase. The 5-HT(7) receptor antagonist (0.25-1.0 mM) induced a significant reduction of REM sleep and of the number of REM periods whereas REM sleep latency was augmented. Pretreatment with the GABA(A) receptor agonist muscimol (1.0-2.0 mM), which by itself did not affect sleep variables, prevented the decrease of REM sleep induced by SB-269970 (1.0 mM). Our results indicate that the 5-HT(7) receptor is involved in the effect of DRN serotonergic (5-HT) neurons on brainstem structures that act to promote and induce REM sleep. We propose that the SB-269970-induced suppression of REM sleep is dependent upon the inhibition of GABA release in the DRN.
在植入用于慢性睡眠记录的成年大鼠中，研究了选择性5-羟色胺（5-HT）7受体拮抗剂SB-269970对自发睡眠的影响。在光照期将SB-269970直接注入中缝背核（DRN）。5-HT7受体拮抗剂（0.25 - 1.0 mM）可显著减少快速眼动睡眠（REM睡眠）和REM睡眠周期的数量，而REM睡眠潜伏期延长。用γ-氨基丁酸A（GABA(A)）受体激动剂蝇蕈醇（1.0 - 2.0 mM）进行预处理，其本身不影响睡眠变量，但可防止SB-269970（1.0 mM）诱导的REM睡眠减少。我们的结果表明，5-HT7受体参与了DRN中5-羟色胺能（5-HT）神经元对脑干结构的作用，这些脑干结构可促进和诱导REM睡眠。我们提出，SB-269970诱导的REM睡眠抑制取决于DRN中GABA释放的抑制。
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