患细支气管炎的婴儿的支气管扩张剂反应性是否取决于年龄？

Does bronchodilator responsiveness in infants with bronchiolitis depend on age?

作者信息

Modl Manfred, Eber Ernst, Malle-Scheid Doris, Weinhandl Elisabeth, Zach Maximilian S

机构信息

Respiratory and Allergic Disease Division, Paediatric Department, Medical University of Graz, Austria.

出版信息

J Pediatr. 2005 Nov;147(5):617-21. doi: 10.1016/j.jpeds.2005.06.005.

DOI:10.1016/j.jpeds.2005.06.005

PMID:16291351

Abstract

OBJECTIVE

To assess the relation between age and bronchodilator responsiveness in infants with bronchiolitis.

STUDY DESIGN

In 41 infants (age, 2 to 18 months) with bronchiolitis, lung function was measured with the raised volume rapid thoracoabdominal compression technique before and after salbutamol inhalation. Lung function was quantified in terms of timed volumes (FEV(0.5), FEV(0.75), and FEV(1.0)). A significant change was defined as a postbronchodilator value that differed from baseline by more than twice the within-subject coefficient of variation.

RESULTS

For the group, postbronchodilator values did not differ significantly from baseline (DeltaFEV(0.5), 3.8% +/- 9.3%; DeltaFEV(0.75), 3.5% +/- 9.5%; and DeltaFEV(1.0), 4.0 +/- 9.8%). Eleven subjects showed significantly increased timed volumes; 3 presented with a decreased lung function; the remaining patients failed to show a significant change. The mean age of subjects with improved lung function did not differ significantly from the mean age of those with no or paradoxical responses (9.7 +/- 4.7 vs 8.1 +/- 4.1 months); there was no correlation of age with the size of the bronchodilator response.

CONCLUSIONS

The results of the current study indicate that bronchodilator responsiveness in infants with bronchiolitis is not age-dependent.

摘要

目的

评估细支气管炎婴儿的年龄与支气管扩张剂反应性之间的关系。

研究设计

对41例年龄在2至18个月的细支气管炎婴儿，在吸入沙丁胺醇前后采用增加容积快速胸腹按压技术测量肺功能。肺功能根据定时容积（FEV(0.5)、FEV(0.75)和FEV(1.0)）进行量化。显著变化定义为支气管扩张剂使用后的值与基线值的差异超过受试者内变异系数的两倍。

结果

对于该组患者，支气管扩张剂使用后的数值与基线值无显著差异（ΔFEV(0.5)，3.8%±9.3%；ΔFEV(0.75)，3.5%±9.5%；以及ΔFEV(1.0)，4.0±9.8%）。11名受试者的定时容积显著增加；3名受试者肺功能下降；其余患者未显示出显著变化。肺功能改善的受试者的平均年龄与无反应或反应异常的受试者的平均年龄无显著差异（9.7±4.7岁对8.1±4.1个月）；年龄与支气管扩张剂反应大小无相关性。