四种不同寻常的双组分信号转导同源物RedC至RedF，对于黄色黏球菌的适时发育是必需的。
Four unusual two-component signal transduction homologs, RedC to RedF, are necessary for timely development in Myxococcus xanthus.
作者信息
Higgs Penelope I, Cho Kyungyun, Whitworth David E, Evans Lisa S, Zusman David R
机构信息
Department of Molecular and Cell Biology, University of California, Berkeley, 94720-3204, USA.
出版信息
J Bacteriol. 2005 Dec;187(23):8191-5. doi: 10.1128/JB.187.23.8191-8195.2005.
Abstract
We identified a cluster of four two-component signal transduction genes that are necessary for proper progression of Myxococcus xanthus through development. redC to redF mutants developed and sporulated early, resulting in small, numerous, and disorganized fruiting bodies. Yeast two-hybrid analyses suggest that RedCDEF act in a single signaling pathway. The previously identified espA gene displays a phenotype similar to that of redCDEF. However, combined mutants defective in espA redCDEF exhibited a striking additive developmental phenotype, suggesting that EspA and RedC to RedF play independent roles in controlling developmental progression.
摘要
我们鉴定出一组四个双组分信号转导基因，它们对于黄色粘球菌正常的发育进程是必需的。redC至redF突变体发育并过早形成孢子，导致子实体小、数量多且杂乱无章。酵母双杂交分析表明RedCDEF在单一信号通路中起作用。先前鉴定出的espA基因表现出与redCDEF相似的表型。然而，espA redCDEF双突变体表现出显著的累加发育表型，这表明EspA和RedC至RedF在控制发育进程中发挥独立作用。
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