Le Bas J-F, Grand S, Kremer S, Tropres I, Jiang Z, Krainik A, Remy C, Berger F, Benabid A-L
Unité IRM et Service de NeuroRadiologie, CHU, Grenoble.
Neurochirurgie. 2005 Sep;51(3-4 Pt 2):287-98. doi: 10.1016/s0028-3770(05)83490-3.
To discuss the pertinency of perfusion MR imaging for initial diagnosis and follow up of brain tumors.
Dynamic susceptibility contrast MR imaging was applied. Images were thus obtained with intensities proportional to the cerebral blood volume (CBV). Relative cerebral blood volume (rCBV) maps were then generated by normalizing the signal intensities with respect to measurements made in healthy tissue.
The method provided interesting data for establishing the differential diagnosis between different kinds of lesions, in particular between lymphoma and pilocytic astrocytoma, and for grading gliomas.
Limits of the approach are discussed, in particular with respect to quantification aspects and interpretation of the results. The approach could be particularly useful for grading oligodendrogliomas, for which histological diagnosis on biopsy is sometimes difficult.
探讨灌注磁共振成像在脑肿瘤初始诊断及随访中的相关性。
采用动态磁敏感对比磁共振成像。由此获得与脑血容量（CBV）成比例的强度图像。然后通过相对于健康组织测量值对信号强度进行归一化来生成相对脑血容量（rCBV）图。
该方法为不同类型病变的鉴别诊断，尤其是淋巴瘤与毛细胞型星形细胞瘤之间的鉴别诊断以及胶质瘤分级提供了有价值的数据。
讨论了该方法的局限性，特别是在定量方面和结果解释方面。该方法对于少突胶质细胞瘤分级可能特别有用，因为活检的组织学诊断有时很困难。
