Pereira Susana Isabel, Adrio Javier, Silva Artur M S, Carretero Juan Carlos
Departamento de Química Orgánica, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
J Org Chem. 2005 Nov 25;70(24):10175-7. doi: 10.1021/jo051701n.
[reaction: see text] Readily available ferrocenyldialkylphosphines are effective air-stable catalysts for Baylis-Hillman reaction between aldehydes and acrylates, affording the corresponding adducts in high yields and short reaction times. A set of readily accessible planar chiral ferrocenyldialkylphosphines have been tested in asymmetric Baylis-Hillman reactions. The best enantioselectivities were obtained using Mandyphos as chiral catalyst (up to 65% ee).
