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Direct determination of the enantiomeric ratio of verapamil, its major metabolite norverapamil and gallopamil in plasma by chiral high-performance liquid chromatography.

作者信息

Fieger H, Blaschke G

机构信息

Institute of Pharmaceutical Chemistry, University of Münster, Germany.

出版信息

J Chromatogr. 1992 Mar 27;575(2):255-60. doi: 10.1016/0378-4347(92)80153-h.

DOI:10.1016/0378-4347(92)80153-h
PMID:1629301
Abstract

Two methods for the determination of the enantiomeric ratio of verapamil in plasma by high-performance liquid chromatography have been developed. On an alpha 1-acid glycoprotein chiral stationary phase (Chiral-AGP) verapamil was separated after the acetylation of the main metabolite norverapamil, which interferes with the resolution of verapamil. On an amylose tris-3,5-dimethylphenylcarbamate column (Chiralpak AD) verapamil and norverapamil were determined simultaneously without prior derivatization. Gallopamil was separated on both columns under similar conditions.

摘要

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