Yoon Myung Ha, Choi Jeong ll, Bae Hong Beom, Kim Seok Jai, Chung Sung Tae, Jeong Seong Wook, Chung Sung Su, Yoo Kyung Yeon, Jeong Chang Yeong
Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, 8 Hakdong, Dongku, Gwangju 501-757, Korea.
Neurosci Lett. 2006 Feb 20;394(3):222-6. doi: 10.1016/j.neulet.2005.10.030. Epub 2005 Nov 15.
Spinal metabotropic glutamate receptors (mGluRs) have been known to be involved in the modulation of nociception. While the antinociceptive effects of the mGluR1/5 have been demonstrated, the role of mGluR2/3 for nociception is less clear. This study investigated the effects of an intrathecal mGluR2/3 agonist, APDC, and a mGluR2/3 antagonist, LY341495, for inflammatory and acute pain in the formalin test and thermal stimulation test. We also examined their interaction with intrathecal morphine for the antinociceptive effect. APDC had little effect on the formalin-induced nociception. In contrast, LY341495 caused a dose-dependent suppression of the phase 2 flinching response to the formalin stimulus without affecting phase 1 flinching response. Furthermore, the suppression of pain behavior by LY341495 during phase 2 was reduced significantly by pretreatment with APDC. LY341495 and morphine also showed synergistic drug interaction for antinociception during phase 2 in the formalin test.
已知脊髓代谢型谷氨酸受体（mGluRs）参与伤害感受的调节。虽然已证实mGluR1/5具有抗伤害感受作用，但mGluR2/3在伤害感受中的作用尚不清楚。本研究在福尔马林试验和热刺激试验中，研究了鞘内注射mGluR2/3激动剂APDC和mGluR2/3拮抗剂LY341495对炎症性疼痛和急性疼痛的影响。我们还研究了它们与鞘内注射吗啡在抗伤害感受作用方面的相互作用。APDC对福尔马林诱导的伤害感受几乎没有影响。相反，LY341495可剂量依赖性地抑制对福尔马林刺激的第2期退缩反应，而不影响第1期退缩反应。此外，APDC预处理可显著降低LY341495在第2期对疼痛行为的抑制作用。在福尔马林试验的第2期，LY341495和吗啡在抗伤害感受方面也表现出协同药物相互作用。
