Haig David
Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA.
Genomics. 2005 Dec;86(6):767-70. doi: 10.1016/j.ygeno.2005.09.016. Epub 2005 Nov 15.
Human chromosome 1 has been claimed to be a conserved ancestral chromosome of eutherian mammals. However, two small regions from distal 1q (with orthology to mouse chromosome 11) appear to have a different history. These two regions are proposed to have been added to the ancestor of human chromosome 1 as a single block that was subsequently disrupted by a paracentric inversion. The translocation and inversion appear to have occurred at some time after the primate lineage diverged from a common ancestor with rodents. Reconstruction of the history of distal human chromosome 1q is complicated by the "reuse" of breakpoints in different mammalian lineages and by coincidental shared synteny between humans and cats.
人类1号染色体被认为是真兽亚纲哺乳动物的一条保守的祖先染色体。然而，1q远端的两个小区域（与小鼠11号染色体具有同源性）似乎有着不同的历史。这两个区域被认为是以单个片段的形式添加到人类1号染色体的祖先中，随后该片段因臂间倒位而被破坏。这种易位和倒位似乎发生在灵长类谱系从与啮齿动物的共同祖先分化出来之后的某个时间。由于不同哺乳动物谱系中断点的“重复利用”以及人类和猫之间偶然的共线性，重建人类1号染色体远端的历史变得复杂。
