Li Xialu, Manley James L
Department of Biological Sciences, Columbia University, New York, New York, USA.
Cell Cycle. 2005 Dec;4(12):1706-8. doi: 10.4161/cc.4.12.2210. Epub 2005 Dec 27.
ASF/SF2 is a well-studied SR protein that plays important roles in premRNA splicing and other aspects of RNA metabolism. Genetic inactivation experiments have revealed the fundamental roles of ASF/SF2 and other SR proteins in cell viability and animal development. However, the nature of the events triggered by in vivo depletion of ASF/SF2 remained largely elusive. Recently, we have demonstrated a significant function of ASF/SF2 in the maintenance of genome stability by preventing the formation of R loops, which provided new insights into the essential roles of ASF/SF2 in cellular physiology.
ASF/SF2是一种经过充分研究的SR蛋白，在pre-mRNA剪接及RNA代谢的其他方面发挥着重要作用。基因失活实验揭示了ASF/SF2及其他SR蛋白在细胞活力和动物发育中的基本作用。然而，体内ASF/SF2缺失所引发事件的本质在很大程度上仍不清楚。最近，我们通过防止R环形成证明了ASF/SF2在维持基因组稳定性方面具有重要功能，这为ASF/SF2在细胞生理学中的重要作用提供了新见解。
