Zhang Weiming, Huang Zhongping, Yu Jianping, Gao Dayong, Qian Jiaqi
Renal Division, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2005 Oct;22(5):1007-10.
The correlations between various formation conditions and the membrane pore characterizations of the anodic alumina membrane were investigated for seeking the optimal conditions for the formation of anodic alumina membrane. High purity aluminum foils were used as the starting materials. The anodizations were conducted under three types of electrolytes, 3% sulfuric acid, 5% sulfuric acid and 2.7% oxalic acid, respectively, with different voltages at 0 degrees C for 48 hours. The characterizations of the pore size, the effective porosity and the pore porosity were observed and determined by scanning electron microscopy. The hydraulic conductance of the membranes was measured to confirm that the pores were open and to evaluate the permselectivity of the membranes. The experimental results showed that the ordered pore arrays were obtained for oxidation under our experimental conditions. While the forming voltage was increasing, the pore size and pore porosity increased significantly (P < 0.05), and the effective porosity decreased significantly (P < 0.05). The pore size formed with 3% sulfuric acid or 5% sulfuric acid was much smaller than that with 2.7% oxalic acid as an electrolyte. The hydraulic conductance of anodic alumina membrane that formed under our experimental condition was high than those of the membranes currently available in clinical procedures. The results suggested that the optimal conditions for the formation of anodic alumina membrane to be used in hemodialysis should be 3% or 5% sulfuric acid with 12.5 V to 17.5 V at 0 degrees C for 48 hours.
为了寻找阳极氧化铝膜形成的最佳条件，研究了各种形成条件与阳极氧化铝膜的膜孔特性之间的相关性。使用高纯度铝箔作为起始材料。分别在三种电解质（3%硫酸、5%硫酸和2.7%草酸）中于0℃、不同电压下进行48小时的阳极氧化。通过扫描电子显微镜观察并确定孔径、有效孔隙率和孔隙孔隙率的特性。测量膜的水力传导率以确认孔是开放的，并评估膜的渗透选择性。实验结果表明，在我们的实验条件下氧化可获得有序的孔阵列。随着形成电压的增加，孔径和孔隙孔隙率显著增加（P<0.05），有效孔隙率显著降低（P<0.05）。以3%硫酸或5%硫酸作为电解质形成的孔径远小于以2.7%草酸作为电解质形成的孔径。在我们的实验条件下形成的阳极氧化铝膜的水力传导率高于目前临床程序中使用的膜。结果表明，用于血液透析的阳极氧化铝膜形成的最佳条件应为在0℃下用3%或5%硫酸、12.5 V至17.5 V、48小时。
