Spencer R P, Knowlton A H
J Nucl Med. 1975 Feb;16(2):123-6.
By use of 99mTc-sulfur colloid, splenic size as well as liver/spleen ratio of ratioactivity was determined after external radiation of the abdomen. In six patients receiving about 2,000 R whole-abdominal radiation, there was no atrophy of the spleen or abnormal distribution in the liver/spleen ratio of radioactivity (that is, the spleen was still functional). Serial studies in a 7-year-old boy with acute lymphoblastic leukemia in remission showed that 1,450 R splenic radiation did not result in any appreciable change in the length of the organ. In a woman with lymphosarcoma, a change in spleen size did not occur until a dose of 1,800 R was delivered. Another patient had apparently normal uptake of radiocolloid 5 years after 3,600 R. Hence the normal spleen and the spleen affected by other diseases may be far more resistant to external radiation than the spleen diseased with chronic myelocytic leukemia. Spleen scans can be useful in documenting the response of the organ to radiation.
通过使用99mTc-硫胶体，在腹部进行外照射后测定脾脏大小以及放射性的肝/脾比值。在6名接受约2000拉德全腹照射的患者中，脾脏没有萎缩，放射性的肝/脾比值也没有异常分布（即脾脏仍有功能）。对一名处于缓解期的7岁急性淋巴细胞白血病男孩进行的系列研究表明，1450拉德的脾脏照射并未导致该器官长度出现任何明显变化。在一名患有淋巴肉瘤的女性中，直到给予1800拉德的剂量后脾脏大小才发生变化。另一名患者在接受3600拉德照射5年后，放射性胶体摄取明显正常。因此，正常脾脏以及受其他疾病影响的脾脏可能比患有慢性粒细胞白血病的脾脏对外照射的耐受性要强得多。脾脏扫描有助于记录该器官对辐射的反应。
