Maclaren N K, Cowles C, Ozand P T, Shuttee R, Cornblath M
J Pediatr. 1975 Jan;86(1):43-9. doi: 10.1016/s0022-3476(75)80702-5.
A 3-yr-old boy was investigated for numerous episodes of fatigue, irritability, pallor, and sweating, which began at 11 mo of age, when he had an episode of symptomatic hypoglycemia with ketonuria. He had euphoria, mental confusion, drowsiness, nausea, and vomiting 1-5 hr after oral administration of glycerol in doses of 0.5-1.0gm/kg. Orally administered MCT (1 gm/kg) had similar effects. On one occasion, oral glycerol also provoked hypoglycemia, as had a 16 1/2 hr fast. Intravenously administered glycerol (0.09 gm/kg) induced an immediate loss of consciousness from which he recovered spontaneously after 30 min; there were no changes in blood glucose values. Intravenously administered fructose (0.25 gm/kg) was tolerated normally. Leukocytes showed normal activities for FDPase, glycerol kinase, and glycerol phosphate dehydrogenase. The restriction of dietary intake of fat has been associated with a marked improvement in physical and mental activities. These observations suggest a unique, yet undifined intolerance to glycerol, which suggest caution in the diagnostic use of glycerol in the investigation of hypoglycemia as well as in the therapy of increased intracranial or intraocular pressure.
一名3岁男孩因多次出现疲劳、易怒、面色苍白和出汗症状接受检查，这些症状始于11个月大时，当时他出现了一次伴有酮尿症的症状性低血糖。口服0.5 - 1.0克/千克剂量的甘油后1 - 5小时，他出现了欣快感、精神错乱、嗜睡、恶心和呕吐。口服中链甘油三酯（1克/千克）也有类似效果。有一次，口服甘油也引发了低血糖，禁食16个半小时也出现了同样情况。静脉注射甘油（0.09克/千克）导致立即失去意识，30分钟后自行恢复；血糖值无变化。静脉注射果糖（0.25克/千克）耐受性正常。白细胞的果糖二磷酸酶、甘油激酶和甘油磷酸脱氢酶活性正常。限制脂肪的饮食摄入与身心活动的显著改善有关。这些观察结果表明对甘油存在一种独特但尚未明确的不耐受性，这提示在低血糖调查以及颅内或眼压升高的治疗中，使用甘油进行诊断时需谨慎。
