生物素对大鼠肝脏中DNA和组蛋白磷酸化的影响。
Effect of biotin on DNA and histone phosphorylation in the rat liver.
作者信息
Petrelli F, Coderoni S, Moretti P, Paparelli M
机构信息
Institute of General Physiology, University of Camerino, Italy.
出版信息
Biochem Exp Biol. 1977;13(4):397-400.
PMID:16296170
Abstract
The results offer further evidence for biotin activity in the phosphorylation mechanism. The decreased 32p incorporation into DNA and histones found in the biotin deficient rat liver is indicative of the importance of the vitamin in the DNA and histones synthesis and in the interactions between histone proteins and DNA, and consequently on the RNA and proteins synthesis.
摘要
这些结果为生物素在磷酸化机制中的活性提供了进一步的证据。在生物素缺乏的大鼠肝脏中，发现32P掺入DNA和组蛋白的量减少，这表明该维生素在DNA和组蛋白合成以及组蛋白与DNA之间的相互作用中具有重要性，进而对RNA和蛋白质合成也具有重要性。
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