Maroni Alessandra, Zema Lucia, Cerea Matteo, Sangalli Maria Edvige
Istituto di Chimica Farmaceutica e Tossicologica, Università di Milano, Italy.
Expert Opin Drug Deliv. 2005 Sep;2(5):855-71. doi: 10.1517/17425247.2.5.855.
In the field of modified release, there has been a growing interest in pulsatile delivery, which generally refers to the liberation of drugs following a programmable lag phase from the time of administration. In particular, the recent literature reports on a variety of pulsatile release systems intended for the oral route, which have been recognised as potentially beneficial to the chronotherapy of widespread diseases, such as bronchial asthma or angina pectoris, with mainly night or early morning symptoms. In addition, time-dependent colon delivery may also represent an appealing related application. The delayed liberation of orally administered drugs has been achieved through a range of formulation approaches, including single- or multiple-unit systems provided with release-controlling coatings, capsular devices and osmotic pumps. Based on these premises, the aim of this review is to outline the rational and prominent design strategies behind oral pulsatile delivery.
在缓控释领域，人们对脉冲给药的兴趣日益浓厚，脉冲给药通常是指药物自给药之时起经过一个可编程的滞后阶段后释放。特别是，近期文献报道了多种用于口服途径的脉冲释放系统，这些系统已被认为对诸如支气管哮喘或心绞痛等主要在夜间或清晨出现症状的广泛疾病的时辰治疗可能有益。此外，时间依赖性结肠给药也可能是一种有吸引力的相关应用。通过一系列制剂方法已实现口服药物的延迟释放，这些方法包括配备控释包衣的单单元或多单元系统、胶囊装置和渗透泵。基于这些前提，本综述的目的是概述口服脉冲给药背后合理且突出的设计策略。
