Ghosh Debaprasad, Jain Anushka, Tyagi Mansi, Katiyar Deepti, Mittal Ashu
KIET School of Pharmacy, KIET Group of Institutions, Delhi-NCR, Ghaziabad, 201206, Uttar Pradesh, India.
Department of Pharmacy, Raj Kumar Goel Institute of Technology (Pharmacy), Ghaziabad, Uttar Pradesh, India.
Comb Chem High Throughput Screen. 2025;28(7):1112-1124. doi: 10.2174/0113862073283113240329064552.
Nutriose is a dextrin-based soluble fiber prepared from starch. Cereals such as maize, wheat, and barley are the primary sources of nutrients for commercial production. Nutriose is resistant to digestion by human enzymes in the stomach and small intestine. It is mostly undamaged when it enters the colon after traveling through the digestive tract, where it generates Short-Chain Fatty Acids (SCFAs) as byproducts. These SCFAs, which include butyrate, propionate, and acetate, have a number of health advantages. They foster an environment in the colon that is advantageous for gut health-promoting bacteria like and . Nutriose fermentation leads to a more balanced composition of the gut microbiota, which may have advantages for the immune system, better digestion, and increased nutrient absorption. As a result, nutriose is currently being utilized as a prebiotic. Several publications have previously demonstrated the impact of nutriose on stimulating gut mucosal immunity and boosting colonic fermentation and excretion in rats. Nanoformulations and nutrisomes have already been prepared and evaluated in recent years. A novel nutriose-based polymeric coating mix has already been tested as a potential colon-targeting material. As a natural polysaccharide, nutriose's possible uses in pharmaceuticals may increase in the near future. The purpose of this study is to critically analyze existing data to determine the potential of nutriose as a natural polymer for various drug delivery systems.
纽特罗斯是一种由淀粉制备的基于糊精的可溶性纤维。玉米、小麦和大麦等谷物是商业生产的主要营养来源。纽特罗斯对胃和小肠中的人类酶消化具有抗性。当它穿过消化道进入结肠时，大部分未被破坏，在结肠中它会产生短链脂肪酸（SCFAs）作为副产品。这些短链脂肪酸包括丁酸、丙酸和乙酸，具有许多健康益处。它们在结肠中营造出有利于促进肠道健康的细菌（如[具体细菌名称1]和[具体细菌名称2]）生长的环境。纽特罗斯发酵导致肠道微生物群组成更加平衡，这可能对免疫系统、更好的消化和增加营养吸收具有益处。因此，纽特罗斯目前正被用作益生元。此前已有多篇文献证明纽特罗斯对刺激大鼠肠道黏膜免疫以及促进结肠发酵和排泄的影响。近年来已经制备并评估了纳米制剂和营养体。一种新型的基于纽特罗斯的聚合物包衣混合物已经作为一种潜在的结肠靶向材料进行了测试。作为一种天然多糖，纽特罗斯在制药领域的潜在用途可能在不久的将来会增加。本研究的目的是批判性地分析现有数据，以确定纽特罗斯作为各种药物递送系统的天然聚合物的潜力。
