Novak N, Peng W M
Department of Dermatology, University of Bonn, Germany.
Clin Exp Immunol. 2005 Dec;142(3):405-10. doi: 10.1111/j.1365-2249.2005.02927.x.
Summary Herpes simplex virus (HSV) represents a smart pathogen, which displays both lytic and latent modes of interaction with its natural human host. In order to be optimally equipped for immune evasion and to reply to any attacks of the host during reactivation, HSV has developed a multitude of cleverly devised defence strategies. Dendritic cells (DC) as antigen-presenting cells located at the border zones of the body and the environment have been shown to play a crucial role as one of the first cells interacting with HSV beside epithelial cells, on one hand, and as important controllers of the viral spreading on the other hand. Here, we provide a research update about the interaction of HSV with DC and summarize the latest proceedings in this field.
摘要 单纯疱疹病毒（HSV）是一种智能病原体，它与人类天然宿主呈现出裂解和潜伏两种相互作用模式。为了在免疫逃避方面具备最佳能力，并在病毒重新激活时应对宿主的任何攻击，HSV已经制定了多种精心设计的防御策略。树突状细胞（DC）作为位于身体与外界交界区域的抗原呈递细胞，一方面已被证明是除上皮细胞外最早与HSV相互作用的细胞之一，发挥着关键作用；另一方面，它也是病毒传播的重要控制者。在此，我们提供关于HSV与DC相互作用的研究进展更新，并总结该领域的最新研究成果。
