Klein Gregory J, Thirion Jean-Philippe
Quantificare, Inc., Oakland, CA 94618, USA.
Biomarkers. 2005 Nov;10 Suppl 1:S1-9. doi: 10.1080/13547500500216934.
Cardiovascular diseases are the leading causes of mortality in western countries, leading to the development of a large set of preventive and curative treatments. Medical imaging is the gold standard to evaluate both cardiac perfusion and cardiac function and can be used even before the advent of hard events to accurately assess treatment effects. This study reviews the different image modalities that can be used to evaluate the evolution of cardiac diseases, especially coronary artery diseases. It also reviews different techniques heavily relying upon image co-registration techniques and population model designs that enable accurate quantitative evaluation of cardiac perfusion and cardiac function through time. It will draw the pros and cons of the different imaging modalities in actual clinical trials: Gated or tagged MRI, MRI for perfusion, PET, SPECT, Gated SPECT, MUGA, Ultrasound. This study also details the latest advances in quantification of cardiac SPECT, which has wide use in clinical trials today.
心血管疾病是西方国家的主要死因，由此催生了大量的预防和治疗方法。医学成像是评估心脏灌注和心脏功能的金标准，甚至在严重事件发生之前就可用于准确评估治疗效果。本研究回顾了可用于评估心脏疾病，尤其是冠状动脉疾病发展情况的不同成像方式。它还回顾了严重依赖图像配准技术和人群模型设计的不同技术，这些技术能够通过时间对心脏灌注和心脏功能进行准确的定量评估。本研究将阐述不同成像方式在实际临床试验中的优缺点：门控或标记磁共振成像、灌注磁共振成像、正电子发射断层扫描、单光子发射计算机断层扫描、门控单光子发射计算机断层扫描、多门电路心血池显像、超声检查。本研究还详细介绍了心脏单光子发射计算机断层扫描定量分析的最新进展，该技术在当今的临床试验中广泛应用。
