致病性奈瑟菌属的天青蛋白参与抵御过氧化氢及在宫颈上皮细胞内的存活。
Azurin of pathogenic Neisseria spp. is involved in defense against hydrogen peroxide and survival within cervical epithelial cells.
作者信息
Wu Hsing-Ju, Seib Kate L, Edwards Jennifer L, Apicella Michael A, McEwan Alastair G, Jennings Michael P
机构信息
The School of Molecular and Microbial Sciences, The University of Queensland, Brisbane 4072, Australia.
出版信息
Infect Immun. 2005 Dec;73(12):8444-8. doi: 10.1128/IAI.73.12.8444-8448.2005.
Abstract
Laz, a lipid-modified azurin of the human pathogens Neisseria gonorrhoeae and Neisseria meningitidis, is involved in defense against oxidative stress and copper toxicity; laz mutant strains are hypersensitive to hydrogen peroxide and copper. The N. gonorrhoeae laz mutant also has decreased survival in an ex vivo primary human ectocervical epithelial assay.
摘要
Laz是人类病原体淋病奈瑟菌和脑膜炎奈瑟菌的一种脂质修饰型蓝铜蛋白，参与抵御氧化应激和铜毒性；laz突变株对过氧化氢和铜高度敏感。淋病奈瑟菌laz突变体在体外原代人宫颈上皮检测中的存活率也有所降低。
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