Lu Ying, Guo Zongru, Guo Yanshen, Feng Jun, Chu Fengming
Department of Synthetic Medicinal Chemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.
Bioorg Med Chem Lett. 2006 Feb 15;16(4):915-9. doi: 10.1016/j.bmcl.2005.10.104. Epub 2005 Nov 21.
A series of 2-alkoxydihydrocinnamates were synthesized as PPARgamma and PPARalpha dual agonists. In vitro studies in cell model showed that these compounds were efficacious. Compound 1g was found to be a potent PPARalpha/gamma dual agonist and will be further evaluated for the treatment of type II diabetes.
合成了一系列2-烷氧基二氢肉桂酸酯作为PPARγ和PPARα双重激动剂。细胞模型中的体外研究表明这些化合物具有效力。发现化合物1g是一种有效的PPARα/γ双重激动剂，将进一步评估其用于治疗II型糖尿病的效果。
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