Synthesis, in vitro and in silico evaluation of l-tyrosine containing PPARalpha/gamma dual agonists.
作者信息
Kumar Rakesh, Ramachandran Uma, Khanna Smriti, Bharatam Prasad V, Raichur Suryaprakash, Chakrabarti Ranjan
机构信息
Department of Pharmaceutical Technology, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. A. S. Nagar 160 062, India.
出版信息
Bioorg Med Chem. 2007 Feb 1;15(3):1547-55. doi: 10.1016/j.bmc.2006.06.063. Epub 2006 Dec 12.
A novel series of l-tyrosine derivatives have been reported with potential PPARalpha/gamma dual agonistic activity. In vitro cell based PPARalpha/gamma transactivation studies have shown compound 4a and compound 4f to be the most potent PPARgamma and PPARalpha activators, respectively. Molecular docking studies performed on these series of compounds have complemented the experimental results and have led to interesting inferences.
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