Kirova Y, Vilcoq J R, Asselain B, Sastre-Garau X, Campana F, Dendale R, Bollet M, Fourquet A
Département de Radiothérapie, Institut Curie, 26, rue d'Ulm, 75005 Paris, France.
Cancer Radiother. 2006 Feb-Mar;10(1-2):83-90. doi: 10.1016/j.canrad.2005.09.027. Epub 2005 Nov 21.
Adjuvant radiotherapy to the breast plays a significant role in preventing local failure in women treated for early stage breast cancer. This fact is supported by multiple clinical trials demonstrating that adjuvant radiotherapy decreases the risk of local recurrence and increases the rate of breast preservation, and actually the rules of adjuvant breast irradiation are clearly established. Sarcomas are a rare but recognized complication of radiation therapy for breast carcinoma, and are associated with poor prognosis. The first case of a bone sarcoma after radiation therapy of breast cancer was described by Beck in 1922. In 1948, Cahan et al. defined the criteria for diagnosis of radiation-induced sarcoma. Since then, some studies have reported the incidence of radiation-induced sarcoma after radiotherapy for different cancers. This article reports and discusses the incidence, management and treatment outcome of radiation-induced sarcomas occurring after radiotherapy for breast cancer in our institute. The incidence, histology, latency of appearance, genesis, their treatment and the prognostic factors of these rare tumors are discussed and the literature is reviewed.
辅助性乳腺放疗在预防早期乳腺癌女性患者的局部复发方面发挥着重要作用。多项临床试验证实了这一事实，这些试验表明辅助性放疗可降低局部复发风险并提高保乳率，实际上辅助性乳腺放疗的规则已明确确立。肉瘤是乳腺癌放疗罕见但已被认识到的并发症，且预后较差。1922年，贝克首次描述了乳腺癌放疗后发生骨肉瘤的病例。1948年，卡汉等人明确了放射性肉瘤的诊断标准。自那时起，一些研究报告了不同癌症放疗后放射性肉瘤的发生率。本文报告并讨论了我院乳腺癌放疗后发生的放射性肉瘤的发生率、管理及治疗结果。讨论了这些罕见肿瘤的发生率、组织学、出现潜伏期、成因、治疗方法及预后因素，并对相关文献进行了综述。
