Salvadori C, Tartarelli C L, Baroni M, Mizisin A, Cantile C
School of Veterinary Medicine, University of Pisa, Animal Pathology, Viale delle Piagge 2, Pisa, I-56124, Italy.
Vet Pathol. 2005 Nov;42(6):852-5. doi: 10.1354/vp.42-6-852.
Neuronal vacuolation and spinocerebellar degeneration in young Rottweiler dogs is a neurodegenerative condition characterized by neuronal vacuolation of several nuclei in the central nervous system and degeneration of the spinal cord white matter. Here, we describe the morphologic and ultrastructural findings in laryngeal muscles and peripheral nerves of a 16-week-old female and a 32-week-old female Rottweiler dog affected by progressive ataxia and tetraparesis associated with laryngeal paralysis. Lesions were characterized by neurogenic muscle atrophy of the intrinsic laryngeal muscles, and a loss of large myelinated fibers in the recurrent laryngeal nerve, accompanied by demyelinating/remyelinating features affecting the small myelinated fibers. No significant changes were detected in the cranial laryngeal, vagus, phrenic, ulnar, or peroneal nerves. These findings were indicative of a selective distal neuropathy of the recurrent laryngeal nerve with early severe axonal degeneration, mainly of the large myelinated fibers.
年轻罗威纳犬的神经元空泡化和脊髓小脑变性是一种神经退行性疾病，其特征是中枢神经系统中多个核团出现神经元空泡化以及脊髓白质变性。在此，我们描述了一只16周龄雌性和一只32周龄雌性罗威纳犬的喉部肌肉和周围神经的形态学和超微结构发现，这两只犬均患有与喉麻痹相关的进行性共济失调和四肢轻瘫。病变的特征为喉内肌的神经源性肌肉萎缩，以及喉返神经中大的有髓纤维缺失，同时伴有影响小的有髓纤维的脱髓鞘/再髓鞘化特征。在喉上神经、迷走神经、膈神经、尺神经或腓神经中未检测到明显变化。这些发现表明喉返神经存在选择性远端神经病变，并伴有早期严重的轴突变性，主要累及大的有髓纤维。
