Rutella Sergio, Zavala Flora, Danese Silvio, Kared Hassen, Leone Giuseppe
Department of Hematology, Laboratory of Immunology, Catholic University School of Medicine, Rome, Italy.
J Immunol. 2005 Dec 1;175(11):7085-91. doi: 10.4049/jimmunol.175.11.7085.
In recent years, several investigators have unraveled a previously unrecognized role for G-CSF in the regulation of T cell and dendritic cell functions. The experimental evidence in favor of G-CSF-mediated immune regulation includes the ability to switch T cell cytokine secretion profile to Th2 responses and the promotion of regulatory T cell and tolerogenic dendritic cell differentiation. Interestingly, G-CSF is beneficial in animals for the prevention and/or treatment of immune-mediated diseases, e.g., graft-vs-host disease, multiple sclerosis, systemic lupus erythematosus, inflammatory bowel disease, and diabetes, suggesting a potential role in human autoimmune diseases. This review summarizes the growing body of evidence that supports a critical role for G-CSF as a novel mediator of T cell tolerance.
近年来，一些研究人员揭示了粒细胞集落刺激因子（G-CSF）在调节T细胞和树突状细胞功能方面以前未被认识的作用。支持G-CSF介导的免疫调节的实验证据包括能够将T细胞细胞因子分泌谱转换为Th2反应，以及促进调节性T细胞和耐受性树突状细胞的分化。有趣的是，G-CSF在动物中对预防和/或治疗免疫介导的疾病有益，例如移植物抗宿主病、多发性硬化症、系统性红斑狼疮、炎症性肠病和糖尿病，这表明其在人类自身免疫性疾病中可能发挥作用。这篇综述总结了越来越多的证据，支持G-CSF作为T细胞耐受性新介质的关键作用。
