环氧化酶-2在子宫内膜癌中的多种作用
Multiple roles of cyclooxygenase-2 in endometrial cancer.
作者信息
Ohno Satoshi, Ohno Yumiko, Suzuki Nobutaka, Inagawa Hiroyuki, Kohchi Chie, Soma Gen-Ichiro, Inoue Masaki
机构信息
Department of Cancer Immunotherapy, Osaka University Graduate School of Medicine, Osaka, Japan.
出版信息
Anticancer Res. 2005 Nov-Dec;25(6A):3679-87.
Cyclooxygenase-2 (COX-2) plays a critical role not only in maintenance of the endometrium during the menstrual cycle, but also in the progression of endometrial cancer. The role of COX-2 in tumor growth and development is complex and multifaceted. This review presents evidence for the expression of COX-2 being linked to angiogenesis, tumor cell apoptosis, tumor cell growth, metastasis and local immunosuppression in cancer progression. It also outlines the clinicopathological and prognostic significance of COX-2 in endometrial cancer.
环氧化酶-2（COX-2）不仅在月经周期中对子宫内膜的维持起着关键作用，而且在子宫内膜癌的进展中也发挥着重要作用。COX-2在肿瘤生长和发展中的作用是复杂且多方面的。本综述提供了证据表明，在癌症进展过程中，COX-2的表达与血管生成、肿瘤细胞凋亡、肿瘤细胞生长、转移及局部免疫抑制相关。同时，本综述还概述了COX-2在子宫内膜癌中的临床病理及预后意义。
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