Gallitto Guiseppe, Serra Salvatore, La Spina Paolino, Postorino Paolo, Laganà Angela, Tripodi Fortunata, Gangemi Santo, Calabrò Salvatore, Savica Rodolpho, Di Perri Raoul, Beghi Ettore, Musolino Rosa
Neurology Unit, University Hospital, Messina, Italy.
Epilepsia. 2005 Nov;46(11):1828-35. doi: 10.1111/j.1528-1167.2005.00278.x.
To estimate the prevalence and define the clinical characteristics of epileptic disorders in the 13,431 residents of the Sicilian Aeolian archipelago, on June 1, 1999.
All established or suspected cases were identified by the neurologists of our working group from available medical information sources. Possible epilepsy cases were then evaluated by the epileptologists by using a standardized questionnaire. The patients were further reviewed by the whole research team to confirm the clinical diagnosis. For a more detailed syndromic definition, some patients underwent EEG or neuroradiologic investigations or both.
The crude point prevalence rate of active epilepsy was 3.13 (95% confidence interval, 2.2-4.2). The prevalence rate age-adjusted to the 2001 Italian population was 3.01. Females had a slightly higher prevalence rate than did males. The highest age-specific prevalence was found in patients aged 5 to 14 years (5.05) and in those aged 65 to 74 years (5.41). Partial seizures with or without secondary generalization were more common (61.7%) than were generalized seizures. Eighty-three percent of cases had symptomatic or cryptogenic localization-related epilepsies, and 8.5% had idiopathic (generalized or partial) epilepsies. Epilepsy was unclassified in 8.5% of cases.
The prevalence of active epilepsy in the Aeolian islands is lower than that in other developed areas, including northern Italy, but is similar to that in Sicily. Partial seizures were the most common type, and localization-related symptomatic epilepsies were the largest syndromic category.
估算1999年6月1日西西里岛伊奥利亚群岛13431名居民中癫痫性疾病的患病率，并确定其临床特征。
我们工作组的神经科医生从现有的医学信息来源中识别出所有确诊或疑似病例。然后，癫痫专家使用标准化问卷对可能的癫痫病例进行评估。整个研究团队对患者进行进一步复查以确认临床诊断。为了更详细地定义综合征，一些患者接受了脑电图或神经放射学检查或两者都接受了检查。
活动性癫痫的粗点患病率为3.13（95%置信区间，2.2 - 4.2）。根据2001年意大利人口年龄调整后的患病率为3.01。女性的患病率略高于男性。特定年龄组患病率最高的是5至14岁的患者（5.05）和65至74岁的患者（5.41）。伴有或不伴有继发性全身性发作的部分性发作比全身性发作更常见（61.7%）。83%的病例患有症状性或隐源性局灶性相关性癫痫，8.5%患有特发性（全身性或部分性）癫痫。8.5%的病例癫痫未分类。
伊奥利亚群岛活动性癫痫的患病率低于包括意大利北部在内的其他发达地区，但与西西里岛相似。部分性发作是最常见的类型，局灶性相关性症状性癫痫是最大的综合征类别。
