Eadie Mervyn J
Department of Medicine, University of Queensland, Royal Brisbane Hospital, Brisbane, Australia.
Epilepsia. 2005 Nov;46(11):1836-40. doi: 10.1111/j.1528-1167.2005.00290.x.
To describe Victor Horsley's contribution to John Hughlings Jackson's understanding of the mechanisms involved in the generalization of convulsive epileptic seizures.
I reviewed Horsley's writings and other relevant late 19th century medical literature.
Horsley's combination of strategically sited surgical lesions and cerebral cortex stimulation studies in experimental animals showed that, contrary to Hughlings Jackson's earlier belief, epileptic activity arising in one cerebral hemisphere had to spread to the contralateral hemisphere before bilateral convulsing could occur.
On the basis of well-designed experiments, Horsley made a major contribution to the understanding of epileptic seizure propagation mechanisms.
描述维克多·霍斯利对约翰·休林斯·杰克逊理解惊厥性癫痫发作泛化机制所做的贡献。
我查阅了霍斯利的著作以及19世纪晚期其他相关医学文献。
霍斯利在实验动物中进行的策略性定位手术损伤与大脑皮层刺激研究相结合的实验表明，与休林斯·杰克逊早期的观点相反，在双侧惊厥发生之前，一个大脑半球产生的癫痫活动必须扩散到对侧半球。
基于精心设计的实验，霍斯利对癫痫发作传播机制的理解做出了重大贡献。
