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复发性细菌性阴道病:治疗后使用维持性酸性阴道凝胶。

Recurrent bacterial vaginosis: the use of maintenance acidic vaginal gel following treatment.

作者信息

Wilson J D, Shann S M, Brady S K, Mammen-Tobin A G, Evans A L, Lee R A

机构信息

Department of Genitourinary Medicine, The General Infirmary at Leeds, Great George Street, Leeds LS1 3EX, UK. janet_d.wilson.nhs.uk

出版信息

Int J STD AIDS. 2005 Nov;16(11):736-8. doi: 10.1258/095646205774763081.

Abstract

Bacterial vaginosis (BV) frequently recurs after treatment. One option in the management of recurrences is to keep the vaginal pH at 4.5 or less, in order to prevent overgrowth of bacteria, until the normal lactobacilli are re-established. We report the outcome of using maintenance acetic acid vaginal gel, after treatment of BV, in a sample of 49 women with frequent recurrences. Half of the women had no further recurrences, and in those who did there was a significant increase in time to first recurrence (4.8 months) after commencing the gel compared with the previous recurrence (2.1 months). Prior to using acidic gel, the mean recurrence rate in 49 women was 4.4 per woman/year, and this was reduced to 0.6 recurrences per woman/year. As there are few effective therapies for women with recurrent BV, we feel this offers an option that can currently be used in clinical practice.

摘要

细菌性阴道病(BV)治疗后常复发。复发管理的一种选择是将阴道pH值保持在4.5或更低,以防止细菌过度生长,直到正常乳酸杆菌重新建立。我们报告了在49例频繁复发的女性样本中,使用维持性醋酸阴道凝胶治疗BV后的结果。一半的女性没有进一步复发,而在有复发的女性中,开始使用凝胶后首次复发的时间(4.8个月)与之前的复发时间(2.1个月)相比有显著增加。在使用酸性凝胶之前,49名女性的平均复发率为每人每年4.4次,而这一数字降至每人每年0.6次复发。由于针对复发性BV女性的有效疗法很少,我们认为这提供了一种目前可用于临床实践的选择。

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