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替硝唑治疗复发性细菌性阴道病

Treatment of recurrent bacterial vaginosis with tinidazole.

作者信息

Baylson F Ariella, Nyirjesy Paul, Weitz M Velma

机构信息

Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.

出版信息

Obstet Gynecol. 2004 Nov;104(5 Pt 1):931-2. doi: 10.1097/01.AOG.0000141551.67833.06.

DOI:10.1097/01.AOG.0000141551.67833.06
PMID:15516381
Abstract

BACKGROUND

Recurrent bacterial vaginosis is a difficult clinical condition. In women with recurrent bacterial vaginosis, relapses are common, even after prolonged courses of maintenance therapy. Because of its spectrum of activity, tinidazole was used in a patient with recurrent bacterial vaginosis.

CASE

A 23-year-old woman taking oral contraceptives had a single sexual partner. She was treated for recurrent bacterial vaginosis with multiple courses of metronidazole gel 0.75%, including regimens of maintenance therapy. The patient experienced repeated recurrences shortly after stopping treatment. A single course of oral tinidazole resulted in a prolonged period where she was free of bacterial vaginosis.

CONCLUSION

Treatment options for recurrent bacterial vaginosis are currently limited. Tinidazole may be a useful option in women with recurrent bacterial vaginosis.

摘要

背景

复发性细菌性阴道病是一种临床难题。在患有复发性细菌性阴道病的女性中,即便经过长时间的维持治疗疗程,复发仍很常见。由于替硝唑的活性谱,其被用于一名复发性细菌性阴道病患者。

病例

一名23岁服用口服避孕药且只有单一性伴侣的女性。她接受了多个疗程的0.75%甲硝唑凝胶治疗复发性细菌性阴道病,包括维持治疗方案。该患者在停止治疗后不久就反复复发。单疗程口服替硝唑使她在较长一段时间内未患细菌性阴道病。

结论

目前复发性细菌性阴道病的治疗选择有限。替硝唑对于患有复发性细菌性阴道病的女性可能是一种有用的选择。

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Antibiotics (Basel). 2021 Jun 15;10(6):719. doi: 10.3390/antibiotics10060719.
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Randomized, double-blind, comparative study of oral metronidazole and tinidazole in treatment of bacterial vaginosis.口服甲硝唑与替硝唑治疗细菌性阴道病的随机、双盲、对照研究
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A comparative study of oral single dose of metronidazole, tinidazole, secnidazole and ornidazole in bacterial vaginosis.
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Guidelines for the treatment of bacterial vaginosis: focus on tinidazole.细菌性阴道病治疗指南:重点关注替硝唑。
Ther Clin Risk Manag. 2009 Jun;5(3):485-9. doi: 10.2147/tcrm.s3777. Epub 2009 Jul 12.
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Findings associated with recurrence of bacterial vaginosis among adolescents attending sexually transmitted diseases clinics.在性传播疾病诊所就诊的青少年中与细菌性阴道病复发相关的研究结果。
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