Sonmez Alper, Dogru T, Yilmaz M I, Ocal R, Ozgurtas T, Kilic S, Eyileten T, Tasci I, Erbil K, Kocar I H
Department of Internal Medicine, Gulhane School of Medicine, Etlik Ankara, Turkey.
Clin Exp Hypertens. 2005 Nov;27(8):629-34. doi: 10.1080/10641960500298673.
CD40 ligand interaction with its receptor (CD40) not only mediates lymphocyte communication, but also associates with chronic inflammation and atherothrombosis. High soluble CD40L (sCD40L) levels were reported in dyslipidemia, diabetes mellitus, and coronary disease. So far, there are no data about sCD40L levels in hypertension. We investigated sCD40L and high sensitive C reactive protein (hsCRP) levels in 30 nonobese young hypertensive men and 30 matched controls. sCD40L and hsCRP levels were not different, and there were no correlations between blood pressure and sCD40L or hsCRP levels. These results might indicate lack of any inflammatory state in new onset hypertension.
CD40配体与其受体（CD40）的相互作用不仅介导淋巴细胞通讯，还与慢性炎症和动脉粥样硬化血栓形成相关。据报道，在血脂异常、糖尿病和冠状动脉疾病中可溶性CD40L（sCD40L）水平较高。到目前为止，尚无关于高血压患者sCD40L水平的数据。我们调查了30名非肥胖年轻高血压男性和30名匹配对照者的sCD40L和高敏C反应蛋白（hsCRP）水平。sCD40L和hsCRP水平无差异，血压与sCD40L或hsCRP水平之间也无相关性。这些结果可能表明新发高血压患者不存在任何炎症状态。
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