Augustyn J M, Ziegler F D
Science. 1975 Feb 7;187(4175):449-50. doi: 10.1126/science.163039.
Rabbits fed a high cholesterol diet experienced a significant increase in plasma adenosine 3,5-monophosphate (cyclic AMP), which was simultaneous with the increase in plasma cholesterol. The content of cyclic AMP in atherosclerotic lesion areas of rabbit aortic intima-media was significantly higher (0.24 picomole per microgram of DNA) than that in adjacent nonlesion areas or in aortic intima-dedia from control animals (0.09 picomole per microgram of DNA). The cyclic AMP content of heart, liver, skeletal muscle, and diaphragm showed no significant elevation in animals fed cholesterol.
喂食高胆固醇饮食的兔子血浆中3,5-环磷酸腺苷（环磷腺苷）显著增加，这与血浆胆固醇的增加同步。兔主动脉内膜-中膜动脉粥样硬化病变区域的环磷腺苷含量（每微克DNA 0.24皮摩尔）显著高于相邻非病变区域或对照动物的主动脉内膜-中膜（每微克DNA 0.09皮摩尔）。喂食胆固醇的动物心脏、肝脏、骨骼肌和膈肌的环磷腺苷含量没有显著升高。
