Challamel M J
INSERM, unité 52, Lyon, France.
Neurophysiol Clin. 1992 Jun;22(2):117-32. doi: 10.1016/s0987-7053(05)80749-x.
The hypotheses directly linked to cognitive and neurologic ontogenic processes ie consolidation of memory and learning, the maturation hypothesis of Roffwarg and the hypothesis of endogenous genetic programming of Jouvet, are analysed. The discussion of these theories are based on the analysis of: the neurophysiologic mechanism of REM sleep and its ontogenesis in human, the results of REM sleep deprivation in young animals and by a personal study of facial mimics during sleep in neonates. Active sleep could be assimilated, very early during ontogenesis, to REM sleep, it probably plays an important role in brain maturation during early development but the stimulation is probably, at this time, not very specific, later it could be a link between genetic programming and epigenetic processes.
分析了与认知和神经发育过程直接相关的假说，即记忆巩固与学习、罗夫瓦尔格的成熟假说以及茹韦的内源性基因编程假说。对这些理论的讨论基于以下分析：快速眼动睡眠的神经生理机制及其在人类中的发生、幼小动物快速眼动睡眠剥夺的结果以及一项关于新生儿睡眠时面部表情的个人研究。在个体发育的早期，主动睡眠可能与快速眼动睡眠相似，它可能在早期发育过程中对大脑成熟起重要作用，但此时的刺激可能不是很具特异性，后来它可能是基因编程与表观遗传过程之间的联系。
