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本文引用的文献

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Depletion of latent HIV-1 infection in vivo: a proof-of-concept study.体内潜伏性HIV-1感染的清除：一项概念验证研究。
Lancet. 2005;366(9485):549-55. doi: 10.1016/S0140-6736(05)67098-5.
2
Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity.慢病毒正反馈回路中的随机基因表达：HIV-1 Tat 波动驱动表型多样性。
Cell. 2005 Jul 29;122(2):169-82. doi: 10.1016/j.cell.2005.06.006.
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Genome-wide analysis of chromosomal features repressing human immunodeficiency virus transcription.抑制人类免疫缺陷病毒转录的染色体特征的全基因组分析。
J Virol. 2005 Jun;79(11):6610-9. doi: 10.1128/JVI.79.11.6610-6619.2005.
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Coaxing HIV-1 from resting CD4 T cells: histone deacetylase inhibition allows latent viral expression.从静息CD4 T细胞中诱导出HIV-1：组蛋白去乙酰化酶抑制可使潜伏病毒表达。
AIDS. 2004 May 21;18(8):1101-8. doi: 10.1097/00002030-200405210-00003.
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HIV reproducibly establishes a latent infection after acute infection of T cells in vitro.在体外对T细胞进行急性感染后，HIV可重复性地建立潜伏感染。
EMBO J. 2003 Apr 15;22(8):1868-77. doi: 10.1093/emboj/cdg188.
6
Direct and quantitative single-cell analysis of human immunodeficiency virus type 1 reactivation from latency.对潜伏状态下的1型人类免疫缺陷病毒激活进行直接和定量的单细胞分析。
J Virol. 2002 Sep;76(17):8776-86. doi: 10.1128/jvi.76.17.8776-8786.2002.
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The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation.人类基因组中HIV-1整合位点决定基础转录活性及对Tat反式激活的反应。
EMBO J. 2001 Apr 2;20(7):1726-38. doi: 10.1093/emboj/20.7.1726.
8
An inducible packaging cell system for safe, efficient lentiviral vector production in the absence of HIV-1 accessory proteins.一种用于在无HIV-1辅助蛋白情况下安全、高效生产慢病毒载体的可诱导包装细胞系统。
Virology. 2001 Mar 30;282(1):77-86. doi: 10.1006/viro.2000.0787.
9
Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding.1型人类免疫缺陷病毒接种增强了病毒结合介导的感染。
J Virol. 2000 Nov;74(21):10074-80. doi: 10.1128/jvi.74.21.10074-10080.2000.
10
Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy.既往病毒储存库与高效抗逆转录病毒治疗中断后血浆病毒血症再次出现之间的关系。
Nat Med. 2000 Jul;6(7):757-61. doi: 10.1038/77481.

用于高通量筛选的1型人类免疫缺陷病毒潜伏模型。

Human immunodeficiency virus type 1 latency model for high-throughput screening.

作者信息

Micheva-Viteva Sofiya, Pacchia Annmarie L, Ron Yacov, Peltz Stuart W, Dougherty Joseph P

机构信息

Department of Molecular Genetics, Microbiology and Immunology, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA.

出版信息

Antimicrob Agents Chemother. 2005 Dec;49(12):5185-8. doi: 10.1128/AAC.49.12.5185-5188.2005.

DOI:10.1128/AAC.49.12.5185-5188.2005
PMID:16304201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1315948/
Abstract

Human immunodeficiency virus type 1 (HIV-1) is not eliminated from patients even after years of antiretroviral therapy, apparently due to the presence of latently infected cells. Here we describe the development of a cell-based system of latency that can be used for high-throughput screening aimed at novel drug discovery to eradicate HIV-1 infection.

摘要

即使经过多年的抗逆转录病毒治疗，1型人类免疫缺陷病毒（HIV-1）仍无法从患者体内清除，这显然是由于存在潜伏感染细胞。在此，我们描述了一种基于细胞的潜伏期系统的开发，该系统可用于高通量筛选，以发现根除HIV-1感染的新型药物。